The role of 7-hydroxymatairezinol in modulation of estrogen metabolism and therapy for mastopathy

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Quantitative estimates of the effect of 7-hydroxymatairesinol (7-HMR) intake on estrogen balance and clinical aspects of the course of fibrocystic mastopathy have been carried out.

Aim. Assessment of effects 7-HMR on metabolism of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, a ratio 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine at patients with fibrous and cystous mastopathy in the post-menopausal period.

Materials and methods. The analysis of metabolites of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, ratios 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine with use of solid-phase immunofermental set (IFA) of «Amerscham International» on the analyzer of Amerkard by means of standard sets is carried out. Statistical 10.0 and Microsoft Excel spreadsheets were used in statistical material processing.

Results. It was found that taking 7-HMR (60 mg/day, 1 month) contributes to normalizing estrogen metabolism (decreasing estradiol, estrone, estriol, 16a-OHE1) and improves the clinical symptoms of mastopathy.

Conclusions. In patients with FCM, 7-HMR contributes to a decrease in hyperestrogenia-related tumor risks by lowering estrogen metabolites levels.

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About the authors

Anna N. Rubashkina

Ivanovo State Medical Academy

Author for correspondence.
ORCID iD: 0000-0002-9639-2525

Russian Federation, Ivanovo

Graduate Student, Ivanovo State Medical Academy

Nina P. Lapochkina

Ivanovo State Medical Academy

ORCID iD: 0000-0001-6722-2810

Russian Federation, Ivanovo

D. Sci. (Med.), Ivanovo State Medical Academy

Ivan Yu. Torshin

Federal Research Center «Informatics and Management»

ORCID iD: 0000-0002-2659-7998
Scopus Author ID: 7003300274

Russian Federation, Moscow

Cand. Sci. (Phys.-Math.), Cand. Sci. (Chem.), Institute of Pharmacoinformatics, Federal Research Center “Computer Science and Control” of RAS

Olga A. Gromova

Federal Research Center «Informatics and Management»; Lomonosov Moscow State University

ORCID iD: 0000-0002-7663-710X
Scopus Author ID: 7003589812

Russian Federation, Moscow

D. Sci. (Med.), Prof., Institute of Pharmacoinformatics, Federal Research Center “Computer Science and Control” of RAS, Lomonosov Moscow State University


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