The role of 7-hydroxymatairezinol in modulation of estrogen metabolism and therapy for mastopathy

Cover Page

Abstract


Quantitative estimates of the effect of 7-hydroxymatairesinol (7-HMR) intake on estrogen balance and clinical aspects of the course of fibrocystic mastopathy have been carried out.

Aim. Assessment of effects 7-HMR on metabolism of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, a ratio 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine at patients with fibrous and cystous mastopathy in the post-menopausal period.

Materials and methods. The analysis of metabolites of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, ratios 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine with use of solid-phase immunofermental set (IFA) of «Amerscham International» on the analyzer of Amerkard by means of standard sets is carried out. Statistical 10.0 and Microsoft Excel spreadsheets were used in statistical material processing.

Results. It was found that taking 7-HMR (60 mg/day, 1 month) contributes to normalizing estrogen metabolism (decreasing estradiol, estrone, estriol, 16a-OHE1) and improves the clinical symptoms of mastopathy.

Conclusions. In patients with FCM, 7-HMR contributes to a decrease in hyperestrogenia-related tumor risks by lowering estrogen metabolites levels.


Full Text

Restricted Access

About the authors

Anna N. Rubashkina

Ivanovo State Medical Academy

Author for correspondence.
Email: Zima_1990@mail.ru
ORCID iD: 0000-0002-9639-2525

Russian Federation, Ivanovo

Graduate Student, Ivanovo State Medical Academy

Nina P. Lapochkina

Ivanovo State Medical Academy

Email: lapochkina_n@mail.ru
ORCID iD: 0000-0001-6722-2810

Russian Federation, Ivanovo

D. Sci. (Med.), Ivanovo State Medical Academy

Ivan Yu. Torshin

Federal Research Center «Informatics and Management»

Email: tiy135@ccas.ru
ORCID iD: 0000-0002-2659-7998
Scopus Author ID: 7003300274

Russian Federation, Moscow

Cand. Sci. (Phys.-Math.), Cand. Sci. (Chem.), Institute of Pharmacoinformatics, Federal Research Center “Computer Science and Control” of RAS

Olga A. Gromova

Federal Research Center «Informatics and Management»; Lomonosov Moscow State University

Email: gromova@gmail.com
ORCID iD: 0000-0002-7663-710X
Scopus Author ID: 7003589812

Russian Federation, Moscow

D. Sci. (Med.), Prof., Institute of Pharmacoinformatics, Federal Research Center “Computer Science and Control” of RAS, Lomonosov Moscow State University

References

  1. Hovelstad H, Leirset I, Oyaas K, Fiksdahl A. Screening analyses of pinosylvin stilbenes, resin acids and lignans in Norwegian conifers. Molecules. 2006; 11 (1): 103–14. doi: 10.3390/11010103
  2. Yamauchi S, Sugahara T, Nakashima Y et al. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem 2006; 70 (8): 1934–40. doi: 10.1271/bbb.60096
  3. Smeds AI, Eklund PC, Willfor SM. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract. Phytochemistry 2016; 130: 207–17. doi: 10.1016/j.phytochem.2016.05.006
  4. Gerstenmeyer E, Reimer S, Berghofer E et al. Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. Food Chem 2013; 138 (2–3): 1847–55. doi: 10.1016/j.foodchem.2012.11.117
  5. Громова О.А., Торшин И.Ю., Рубашкина А.Н. и др. Систематический анализ фундаментальных и клинических исследований лигнана 7-гидроксиматаирезинола. Эффективная фармакотерапия. 2019; 15(13): 34–41. doi: 10.33978/2307-3586-2019-15-13-34-41 [Gromova O.A., Torshin I.Iu., Rubashkina A.N. et al. Sistematicheskii analiz fundamental’nykh i klinicheskikh issledovanii lignana 7-gidroksimatairezinola. Effektivnaia farmakoterapiia. 2019; 15(13): 34–41. doi: 10.33978/2307-3586-2019-15-13-34-41 (in Russian).]
  6. Громова О.А., Рубашкина А.Н., Филимонова М.В. и др. Адъювантная терапия лигнаном 7-гидроксиматаирезинолом как метод повышения онкологической безопасности приема эстрогенов. Эффективная фармакотерапия. 2018; 13: 14–9. [Gromova O.A., Rubashkina A.N., Filimonova M.V. et al. Ad»iuvantnaia terapiia lignanom 7-gidroksimatairezinolom kak metod povysheniia onkologicheskoi bezopasnosti priema estrogenov. Effektivnaia farmakoterapiia. 2018; 13: 14–9 (in Russian).]
  7. Статистика злокачественных новообразований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М., 2014. [Statistics of malignant tumors in Russia and CIS countries in 2012. Ed. by М.I. Davydov, Е.М. Аxel. Мoscow, 2014 (in Russian).]
  8. Адамян Л.В., Андреева Е.Н., Артымук Н.В. и др. Доброкачественная дисплазия молочной железы. Клинические рекомендации (протокол), утв. МЗ РФ 07 ноября 2018 № 15-4/10/2-7235. М., 2018. [Adamyan L.V., Andreeva E.N., Artymuk N.V. et al. Benign breast dysplasia. Clinical recommendations (protocol), approved. Ministry of Health of the Russian Federation on November 07, 2018 No. 15-4/10/2-7235. Мoscow, 2018 (in Russian).]
  9. Каприн А.Д., Рожкова Н.И. Мастопатии. М.: ГЭОТАР-Медиа, 2019. (in Russian).] [Kaprin A.D., Rozhkova N.I. Mastopathy. Мoscow: GEOTAR-Media, 2019 (in Russian).]
  10. Torshin IYu. Optimal Dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognition and Image Analysis 2013; 23 (2): 319–27.
  11. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26 (3): 483–96.
  12. Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27 (2): 184–99.
  13. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16 alрfahydroxyesterone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1998; 85: 7831–35.
  14. Киселев В.И., Ляшенко А.А. Молекулярные механизмы регуляции гиперпластических процессов. М.: Димитрейд График Групп, 2005. [Kiselev V.I., Lyashenko А.А. Molecular mechanisms of the regulation of hyperplastic processes. Мoscow: Dimitreid Grafik Grupp, 2005 (in Russian).]
  15. Сlemons M, Goss P. Estrogen and risk of breast cancer. N Engl J Med 2001; 344 (4): 276–85.
  16. Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. Part I: MEmbrane-associated signaling complexes. TRENDS Endocrinol Metab 2002; 13 (8): 349–54.
  17. Zou JX, Revenko AS, Li LB et al. ANCCA, an estrogen-regulated AAA+ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA 2007; 104 (46): 18067–72. doi: 10.1073/pnas.0705814104
  18. Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem 2011; 286 (20): 17746–54. doi: 10.1074/jbc.M110.206029
  19. Dhananjayan SC, Ramamoorthy S, Khan OY et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol 2006; 20 (10): 2343–54. doi: 10.1210/me.2005-0533
  20. Britschgi A, Duss S, Kim S et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. Nature 2017; 541 (7638): 541–5. doi: 10.1038/nature20829
  21. Lee YF, Young WJ, Lin WJ et al. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem 1999; 274 (23): 16198–205. doi: 10.1074/jbc.274.23.16198
  22. Van Agthoven T, van Agthoven TL, Dekker A et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17 (10): 2799–808. doi: 10.1093/emboj/17.10.2799

Supplementary files

There are no supplementary files to display.

Statistics

Views

Abstract - 8

PDF (Russian) - 0

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies