Experience in the treatment of chronic endometritis

Cover Page

Abstract


At present, bacterial biofilms play a significant role in chronic endometritis. In our clinical case, a patient with a history of infertility has had no sex life for several years, but bacterial vaginosis recurs monthly. Ascending bacterial infection with chronic endometritis was confirmed by immunohistochemistry data (detection of CD138), as well as microbiological data (detection of anaerobic microorganisms, including Gardnerella vaginalis and Atopobium vagine, in the endometrium). To treat chronic endometritis, we used antibiotic moxifloxacin, followed by administration of bovhyaluronidase azoximer (Longidaza®) in the form of rectal suppositories. As a result of complex therapy, the patient’s endometrium improved (CD138 and anaerobic bacteria revealed), subsequent repeated insemination with donor sperm led to the onset of progressive pregnancy.


Full Text

Restricted Access

About the authors

N. I. Tapilskaya

Ott Research Institute of Obstetrics, Gynecology and Reproductology; Saint Petersburg State Pediatric Medical University

Author for correspondence.
Email: tapnatalia@yandex.ru
ORCID iD: 0000-0001-5309-0087

Russian Federation, Saint Petersburg

D. Sci. (Med.), Prof., Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg State Pediatric Medical University

Alevtina M. Savicheva

Ott Research Institute of Obstetrics, Gynecology and Reproductology; Saint Petersburg State Pediatric Medical University

Email: savitcheva@mail.ru
ORCID iD: 0000-0003-3870-5930

Russian Federation, Saint Petersburg

D. Sci. (Med.), Prof., Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg State Pediatric Medical University

Kira V. Shalepo

Ott Research Institute of Obstetrics, Gynecology and Reproductology; Saint Petersburg State Pediatric Medical University

Email: 2474151@mail.ru
ORCID iD: 0000-0002-3002-3874

Russian Federation, Saint Petersburg

Cand. Sci. (Biol.), Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg State Pediatric Medical University

Anastasiya A. Kopylova

Ott Research Institute of Obstetrics, Gynecology and Reproductology

Email: iagmail@ott.ru
ORCID iD: 0000-0002-6387-4878

Russian Federation, Saint Petersburg

Graduate Student, Ott Research Institute of Obstetrics, Gynecology and Reproductology

References

  1. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. Руководство. М.: ГЭОТАР-Медиа, 2010. [Sukhikh G.T., Shurshalina A.V. Chronic endometritis. Leadership. Moscow: GEOTAR-Media, 2010 (in Russian).]
  2. Горбачева Т.И., Востриков В.В. Факторы риска неудач экстракорпорального оплодотворения при хроническом эндометрите. Вестн. НГУ. Сер.: Биология, клиническая медицина. 2013; 11 (2): 99–104. [Gorbacheva T.I., Vostrikov V.V. Faktory riska neudach ekstrakorporal’nogo oplodotvoreniia pri khronicheskom endometrite. Vestn. NGU. Ser.: Biologiia, klinicheskaia meditsina. 2013; 11 (2): 99–104 (in Russian).]
  3. Фэн И., Сидорова И.С., Станоевич И.В. и др. Сочетание гиперпластических процессов эндометрия с хроническим эндометритом. Акушерство, гинекология, репродукция. 2012; 6 (1): 31–3. [Fen I., Sidorova I.S., Stanoevich I.V. et al. Sochetanie giperplasticheskikh protsessov endometriia s khronicheskim endometritom. Akusherstvo, ginekologiia, reproduktsiia. 2012; 6 (1): 31–3 (in Russian).]
  4. Hall-Stoodley L, Stoodley P, Kathju S et al. Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol 2012; 65: 127–45.
  5. Lebeaux D, Chauhan A, Rendueles O, Beloin C. From in vitro to in vivo models of bacterial biofilm-related infections. Pathogens 2013; 2 (2): 288–356.
  6. Bjarnsholt T, Ciofu O, Molin S et al. Applying insights from biofilm biology to drug development – can a new approach be developed? Nat Rev Drug Dis 2013; 12 (10): 791–808.
  7. Swidsinski A, Loening-Baucke V, Swidsinski S, Dörffel Y. Infection through structured polymicrobial gardnerella biofilms (STPM-GB). Акушерство. Гинекология. Генетика. 2016; 2 (4): 51–73. [Swidsinski A, Loening-Baucke V, Swidsinski S, Dörffel Y. Infection through structured polymicrobial gardnerella biofilms (STPM-GB). Akusherstvo. Ginekologiia. Genetika. 2016; 2 (4): 51–73 (in Russian).]
  8. Трошин Н.А. Влияние лонгидазы на микробный пейзаж цервикального канала и полости матки при лечении женщин с хроническим неспецифическим эндометритом и миомой матки. Журн. микробиологии, эпидемиологии и иммунобиологии. 2015; 4: 71–4. [Troshin N.A. Vliianie longidazy na mikrobnyi peizazh tservikal’nogo kanala i polosti matki pri lechenii zhenshchin s khronicheskim nespetsificheskim endometritom i miomoi matki. Zhurn. mikrobiologii, epidemiologii i immunobiologii. 2015; 4: 71–4 (in Russian).]
  9. Лонгидаза® (Longidaza). Инструкция по применению. [Longidaza® (Longidaza). Instructions for use (in Russian).]
  10. Тризна Е.Ю., Каюмов А.Р. Влияние in vitro изолированного и сочетанного с антибактериальными средствами применения бовгиалуронидазы азоксимер на целостность бактериальной биопленки и жизнеспособность микроорганизмов. Экспериментальная и клиническая фармакология. 2020; 83 (2): 38–44. [Trizna E.Iu., Kaiumov A.R. Vliianie in vitro izolirovannogo i sochetannogo s antibakterial’nymi sredstvami primeneniia bovgialuronidazy azoksimer na tselostnost’ bakterial’noi bioplenki i zhiznesposobnost’ mikroorganizmov. Eksperimental’naia i klinicheskaia farmakologiia. 2020; 83 (2): 38–44 (in Russian).]

Supplementary files

There are no supplementary files to display.

Statistics

Views

Abstract - 10

PDF (Russian) - 1

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies