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The method of hermetic sealing of iatrogenic damage of fetal membranes during fetal surgical interventions
- Authors: Shneyderman MG1, Fatkhudinov TK.1, Tetruashvili NK1, Kostyukov KV1, Sakalo VA1, Arutyunyan IV1, Gladkova KA1, Shmakov RG1
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Affiliations:
- V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
- Issue: Vol 20, No 1 (2018)
- Pages: 84-87
- Section: Articles
- URL: https://gynecology.orscience.ru/2079-5831/article/view/30060
- DOI: https://doi.org/10.26442/2079-5696_20.1.84-87
- ID: 30060
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Abstract
The article presents a new method for treating iatrogenic damage to membranes in fetuscopic interventions. Since surgical treatment during pregnancy is associated with the use of trocar and amniotic fetal puncture, the most frequent complication of this procedure is premature discharge of amniotic fluid and abortion (28-67%). The new method of treatment is based on the use of the technique of safe and effective hermetic sealing of fetal membranes in fetoscopy, which will reduce the frequency of iatrogenic complications. The Ministry of Health of the Russian Federation has developed a method and created the main components for hermetic sealing of membranes: a tissue sealant from the blood components of the mother - a plasma enriched with platelets, which can be injected into the area of the defect of the fetal bladder in the form of a gel and an amniotic catheter providing effective sealing of the trocar hole from the inner and outer surfaces of the membranes. We described the results of a laboratory experiment on animals, discussed the effectiveness of a new method of treatment and the possibility of its practical application.
Full Text
The article presents a new method for treating iatrogenic damage to membranes in fetuscopic interventions. Since surgical treatment during pregnancy is associated with the use of trocar and amniotic fetal puncture, the most frequent complication of this procedure is premature discharge of amniotic fluid and abortion (28-67%). The new method of treatment is based on the use of the technique of safe and effective hermetic sealing of fetal membranes in fetoscopy, which will reduce the frequency of iatrogenic complications. The Ministry of Health of the Russian Federation has developed a method and created the main components for hermetic sealing of membranes: a tissue sealant from the blood components of the mother - a plasma enriched with platelets, which can be injected into the area of the defect of the fetal bladder in the form of a gel and an amniotic catheter providing effective sealing of the trocar hole from the inner and outer surfaces of the membranes. We described the results of a laboratory experiment on animals, discussed the effectiveness of a new method of treatment and the possibility of its practical application.About the authors
M G Shneyderman
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: innamike@lmi.net
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
T Kh Fatkhudinov
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: tfat@yandex.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
N K Tetruashvili
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: tetrauly@mail.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
K V Kostyukov
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: kostyukov_k@yahoo.com
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
V A Sakalo
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: v_sakalo@oparina4.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
I V Arutyunyan
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: tfat@yandex.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
K A Gladkova
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Email: k_gladkova@oparina4.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
R G Shmakov
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: mdshmakov@mail.ru
д-р мед. наук, глав. врач
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4References
- Beck V, Pexsters A, Gucciardo L еt al. The use of endoscopy in fetal medicine. Gynecol Surg 2010; 7: 113-25.
- Devlieger R, Millar L.K, Bryant-Greenwood G et al. Deprest Fetal membrane healing after spontaneous and iatrogenic membrane rupture: A review of current evidence American. J Obstet Gynecol 2006; 195: 1512-20.
- Deprest J, Emonds M.P, Richter J. et al. Amniopatch for iatrogenic rupture of the fetal membranes. Prenat Diagn 2011; 31 (7): 661-6. doi: 10.1002/pd.2780.
- Mann L.K, Papanna R, Moise K.J et al. Fetal membrane patch and biomimetic adhesive coacervates as a sealant for fetoscopic defects. Acta Biomaterialia 2012; 8: 2160-5.
- Liekens D, Lewi L, Jani J. et al. Deprest Enrichment of collagen plugs with platelets and amniotic fluid cells increases cell proliferation in sealed iatrogenic membrane defects in the foetal rabbit model. J Prenat Diagn 2008; 28 (6): 503-7. doi: 10.1002/pd.2010
- Farmer D. Fetal surgery. BMJ 2003; 326: 461-2.
- Harrison M.R, Golbus M.S, Filly R.A et al. Fetal surgery for congenital hydronephrosis. N Engl J Med 1982; 306: 591-3В.
- Harrison M.R. Surgically correctable fetal disease. Am J Surg 2000; 180: 335-42.
- Шнейдерман М.Г., Фатхудинов Т.Х., Костюков К.В. и др. Разработка способа герметизации ятрогенных разрывов плодных оболочек в процессе проведения фетальных операций. Материалы ХХХ Юбилейного международного конгресса с курсом эндоскопии «Новые технологии в диагностике и лечении гинекологических заболеваний». Москва, 6-9 июня 2017 г.; с. 169-70.
- Шнейдерман М.Г., Фатхудинов Т.Х., Костюков К.В. и др. «Перинатальная медицина - от истоков к современности». Тр. научно-практич. конференции, посвященной 140-летию ФГБУ «НИИ ОММ» Минздрава России, 13-14 октября 2017 г.
- Schneiderman M, Kostyukov K, Fatkhudinov T et al. A New Method for Preventing the Iatrogenic Breaks of Fetal Membrane and Amniotic Fluid Disposal in Fetal Surgery and a New Amniotic Catheter Model for its Implementation. 10th American Pediatrics Healthcare Congress, September 20-22, 2017, Toronto, Canada.
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