Age-related changes in heart rate variability from the neonatal period to adulthood

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The aim of the study was to reveal the regularities of the age-related dynamics of the frequency-dependent regulation of heart rate variability (HRV) based on the analysis of Holter ECG recordings from healthy subjects of 4 age groups: neonates, one-year-old infants, adolescents and adults. A wide spectral composition of HRV is shown, consisting of 9 Gilbert-Huang modes in the frequency range from 0.0001 to 2 Hz. A decrease in the central frequencies of all modes is shown in the postnatal period with a plateau in adolescence. A rapid progression of systemic humoral regulation of HRV, characterized by a consolidated increase in the amplitudes of the corresponding modes with a plateau in adolescence, is demonstrated. The dome-shaped character of age-related changes in amplitude of modes associated with autonomic control with a maximum in adolescence is shown. The results obtained quantitatively demonstrate age-related consolidated changes in HRV parameters from neonates to adulthood.

About the authors

A. A. Grinevich

Institute of Cell Biophysics of Russian Academy of Sciences

Author for correspondence.
Email: grin_aa@mail.ru
Russian Federation, Pushchino

N. K. Chemeris

Institute of Cell Biophysics of Russian Academy of Sciences

Email: grin_aa@mail.ru
Russian Federation, Pushchino

References

  1. Анохин П.К. Принципиальные вопросы общей теории функциональных систем. В кн.: Принципы системной организации функций. М. Наука; 1973. С. 5-61.
  2. Судаков К.В. Общие закономерности динамической организации функциональных систем // Человек и его здоровье. 2005. №2. С. 4-13.
  3. Судаков К.В. Информация в деятельности функциональных систем организма // Вестник ЧелГУ. 2009. №11. С. 35-46.
  4. Ivanov P.C., Liu K.K.L., Bartsch R.P. Focus on the emerging new fields of Network Physiology and Network Medicine // New J Phys. 2016. Vol. 18. P. 100201.
  5. Ivanov P.C. The New Field of Network Physiology: Building the Human Physiolome // Front Netw Physiol. 2021. Vol. 1. P. 711778.
  6. Stefanovska A., McClintock P.V.E, editors. Physics of Biological Oscillators. Cham: Springer; 2021.
  7. Task Force of the European Society of Cardiology, and the North American Society of Pacing and Electrophysiology. Heart rate variability standards of measurement, physiological interpretation and clinical use // Eur. Heart J. 1996. Vol. 17. P. 354–381.
  8. Гриневич А.А., Чемерис Н.К. Спектральный анализ вариабельности сердечного ритма на основе метода Гильберта-Хуанга // Доклады Российской академии наук. Науки о жизни. 2023. Т. 511. С. 395–398.
  9. Соболев А.В., Рябыкина Г.В., Кожемякина Е.Ш. Новый метод анализа вариабельности синусового ритма на длительных промежутках времени, учитывающий наличие на ритмограмме двойных изломов // Медицинский алфавит. 2017. Т. 1, № 14. С. 22-27.
  10. Курбонбекова А.В. Соболев Е.Ш. Кожемякина Т.М. и др. Анализ динамики суточной вариабельности синусового ритма по данным Холтеровского мониторирования для оценки эффективности лечения больных легочной гипертензией // Медицинский алфавит. 2022. № 20. С. 29-35.
  11. Huang N.E., Zheng S., Steven R.L., et al. The Empirical Mode Decomposition and the Hilbert Spectrum for Nonlinear and Non-Stationary Time Series Analysis // Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences. 1998. Vol. 454. P. 903–95.
  12. Irurzun I.M., Garavaglia L., Defeo M.M., et al. RR interval time series from healthy subjects (version 1.0.0) // PhysioNet. 2021.
  13. Goldberger A., Amaral L., Glass L., et al. PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals // Circulation [Online]. 2000. Vol. 101, № 23. P. e215–e220.
  14. Chiera M., Cerritelli F., Casini A., et al. Heart Rate Variability in the Perinatal Period: A Critical and Conceptual Review // Front Neurosci. 2020. Vol. 14. P. 561186.
  15. Harteveld L.M., Nederend I. Harkel A.D.J., et. al. Maturation of the Cardiac Autonomic Nervous System Activity in Children and Adolescents // J Am Heart Assoc. 2021. Vol. 10. P. e017405.
  16. Patural H., Franco P., Pichot V., et al. Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion // Front Pediatr. 2022. Vol. 10. P. 860145.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Russian Academy of Sciences