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Vol 518, No 1 (2024)
CHEMISTRY
Special approaches for the synthesis and use of peptide fragments and their analogues in the design of medicines. A Review
Abstract
A number of modern methods for the preparation of hybrid compounds using peptide fragments are described. Biologically active compounds were modified using organic acids, proline (Pro-Gly-Pro) and phosphinate fragments. The methods of synthesis of hybrid compounds that can be used to obtain organic compounds labeled with hydrogen isotopes are shown. Cytotoxicity, specific binding of synthesized compounds to receptor systems and other characteristics of these compounds have been studied.
3-22
Preparation of copper and nickel based nanoparticles by magnetron sputtering and their use in sulfur–sulfur bond activation reaction
Abstract
The present work is devoted to a systematic study of the advantages and limitations of the magnetron sputtering method, which is a convenient and promising way to obtain nanosized particles directly from the bulk metal, when it is used to prepare nanoparticles of the first-row transition metals. In the course of the study, variation of sputtering media based on ionic liquids, eutectic solvents, low and high molecular weight organic compounds was carried out. Particles of copper, nickel, a copper-nickel alloy and a copper-zinc alloy were obtained. Using the example of the activation reaction of the sulfur–sulfur bond in diphenyl disulfide, it has been shown that up to 96% of the sputtered copper can be effectively used in catalysis, whereas in the case of nickel and zinc about three quarters of the metal can be converted to an inactive form, at the same time readily oxidizable components can act as sacrificial stabilizers for moderately active metal particles in sputtering two-component alloys.
23-31
CHEMICAL TECHNOLOGY
Study of the influence of fillers on the wettibility and cytotoxicity of polysiloxane films for medical use
Abstract
A method for synthesis of two new types of polysiloxane-based films is proposed: with introduced chitosan and with introduced sodium bicarbonate with its subsequent removal. It was found that the obtained films have a branched internal structure of channels suitable for further filling with biologically active substances. The study of the hydrophobicity of the obtained films, in comparison with pure polysiloxane films, showed an insignificant (no more than 6%) decrease in the equilibrium wetting edge angle, as well as equalization of its values from the outer and inner sides, compared with films without modification. A comprehensive in vitro study demonstrated the promising use of polysiloxane films with introduced chitosan, since they do not have a reliable toxic effect on the studied cells. Films of pure polysiloxane and polysiloxane with the use of sodium hydrogen carbonate had a toxic effect on the investigated cells and acidified the medium. All samples were found to be non-adhesive to cells.
32-40
PHYSICAL CHEMISTRY
Luminescence of lanthanide complexes in nano anion exchangers
Abstract
The possibility of using nanoanion exchangers as an organized medium for enhancing the luminescence of rare earth element complexes has been demonstrated for the first time. When a sol formed by anion exchanger nanoparticles is introduced into a solution containing thenoyltrifluoroacetone (TTA) and traces of europium(III) or samarium(III) salts, TTA anions concentrate in the ionite phase and bind rare earth cations into negatively charged complexes, which is accompanied by an increase in luminescence intensity by three orders of magnitude.
41-44