Synthesis of symmetrical 1,3-bis(polyfluorophenyl)ureas based on polyfluorobenzoic acid chlorides with potential antimicrobial action

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Abstract

A one-pot method for the synthesis of symmetrical 1,3-bis(polyfluorophenyl)ureas based on an interaction of polyfluorobenzoic acid chlorides with sodium azide and subsequent Curtius rearrangement has been developed. It was found that 1,3-bis(3,4,5-trifluoro-2-methoxyphenyl)urea has a fungistatic effect on pathogenic dermatophyte strains and high antigonorrheal activity.

About the authors

A. D. Baranovskiy

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

620066 Ekaterinburg, Russian Federation

E. V. Shchegolkov

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

620066 Ekaterinburg, Russian Federation

Ya. V. Burgart

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

620066 Ekaterinburg, Russian Federation

N. A. Gerasimova

Ural Research Institute for Dermatology, Venereology and Immunopathology

620076 Ekaterinburg, Russian Federation

N. P. Evstigneeva

Ural Research Institute for Dermatology, Venereology and Immunopathology

620076 Ekaterinburg, Russian Federation

V. I. Saloutin

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: saloutin@ios.uran.ru
620066 Ekaterinburg, Russian Federation

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