Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
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Аннотация

This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

Авторлар туралы

Т. Garaev

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

I. Yudin

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

N. Breslav

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

Т. Savochkina

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

А. Krepkaya

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

Т. Grebennikova

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

S. Nikiforova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

I. Myshletsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

V. Avdeeva

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: avdeeva.varvara@mail.ru
Ресей, Moscow

Е. Malinina

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Ресей, Moscow

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