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The role of BDNF in the antidepressant effects of electroconvulsive therapy
- Authors: Ushakova V.M.1,2, Zubkov E.A.1, Morozova A.Y.1, Pavlov K.A.1, Zorkina Y.A.1, Abramova O.V.1, Ochneva A.G.1, Gurina O.I.1, Tarkovskaya K.S.1, Inozemtsev A.N.2, Chekhonin V.P.1,3
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Affiliations:
- V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
- Lomonosov Moscow State University
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 519, No 1 (2024)
- Pages: 42-46
- Section: Articles
- URL: https://gynecology.orscience.ru/2686-7389/article/view/651379
- DOI: https://doi.org/10.31857/S2686738924060069
- ID: 651379
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Abstract
Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20–45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In the future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.
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About the authors
V. M. Ushakova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health; Lomonosov Moscow State University
Author for correspondence.
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology, Department of Higher Nervous Function
Russian Federation, Moscow; MoscowE. A. Zubkov
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowA. Y. Morozova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowK. A. Pavlov
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowY. A. Zorkina
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowO. V. Abramova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowA. G. Ochneva
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowO. I. Gurina
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Corresponding Member of RAS, Department of Basic and Applied Neurobiology
Russian Federation, MoscowK. S. Tarkovskaya
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
Russian Federation, MoscowA. N. Inozemtsev
Lomonosov Moscow State University
Email: ushakovavm@yandex.ru
Department of Higher Nervous Function
Russian Federation, MoscowV. P. Chekhonin
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health; The Russian National Research Medical University named after N.I. Pirogov
Email: ushakovavm@yandex.ru
Academician of the RAS, Department of Basic and Applied Neurobiology, Department of Medical Nanobiotechnologies
Russian Federation, Moscow; MoscowReferences
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