电邮这篇文章 The role of BDNF in the antidepressant effects of electroconvulsive therapy
- 作者: Ushakova V.M.1,2, Zubkov E.A.1, Morozova A.Y.1, Pavlov K.A.1, Zorkina Y.A.1, Abramova O.V.1, Ochneva A.G.1, Gurina O.I.1, Tarkovskaya K.S.1, Inozemtsev A.N.2, Chekhonin V.P.1,3
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隶属关系:
- V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
- Lomonosov Moscow State University
- The Russian National Research Medical University named after N.I. Pirogov
- 期: 卷 519, 编号 1 (2024)
- 页面: 42-46
- 栏目: Articles
- URL: https://gynecology.orscience.ru/2686-7389/article/view/651379
- DOI: https://doi.org/10.31857/S2686738924060069
- ID: 651379
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详细
Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20–45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In the future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.
作者简介
V. Ushakova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health; Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology, Department of Higher Nervous Function
俄罗斯联邦, Moscow; MoscowE. Zubkov
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowA. Morozova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowK. Pavlov
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowY. Zorkina
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowO. Abramova
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowA. Ochneva
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowO. Gurina
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Corresponding Member of RAS, Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowK. Tarkovskaya
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health
Email: ushakovavm@yandex.ru
Department of Basic and Applied Neurobiology
俄罗斯联邦, MoscowA. Inozemtsev
Lomonosov Moscow State University
Email: ushakovavm@yandex.ru
Department of Higher Nervous Function
俄罗斯联邦, MoscowV. Chekhonin
V. Serbsky National Medical Research Centre of Psychiatry and Narcology under the RF Ministry of Public Health; The Russian National Research Medical University named after N.I. Pirogov
Email: ushakovavm@yandex.ru
Academician of the RAS, Department of Basic and Applied Neurobiology, Department of Medical Nanobiotechnologies
俄罗斯联邦, Moscow; Moscow参考
- Malhi G.S., Mann J.J. Depression // Lancet. 2018. Vol. 392. P. 2299–2312.
- Kellner C.H., Kaicher D.C., Banerjee H., et al. Depression severity in electroconvulsive therapy (ECT) versus pharmacotherapy trials // The journal of ECT. 2015 Vol. 31. P. 31–33.
- Kritzer M.D., Peterchev A.V., Camprodon J.A. Electroconvulsive Therapy: Mechanisms of Action, Clinical Considerations, and Future Directions // Harvard review of psychiatry. 2023. Vol. 31, N 3. P. 101–113.
- Réus G.Z., de Moura A.B., Borba L.A., et al. Strategies for Treatment-Resistant Depression: Lessons Learned from Animal Models // Molecular neuropsychiatry. 2019. Vol. 5, N 4. P. 178–189.
- Subramanian S., Lopez R., Zorumski C.F., et al. Electroconvulsive therapy in treatment resistant depression // Journal of the neurological sciences. 2022. Vol. 434:120095.
- Maffioletti E., Carvalho Silva R., Bortolomasi M., et al. Molecular Biomarkers of Electroconvulsive Therapy Effects and Clinical Response: Understanding the Present to Shape the Future // Brain sciences. 2021. Vol. 11, N 9: 1120.
- Ушакова В.М., Зубков Е.А., Морозова А.Ю., и др. Влияние электросудорожной терапии на когнитивные функции крыс при депрессивно-подобном состоянии // Бюллетень экспериментальной биологии и медицины. 2017. Т. 163. № 5. С. 549–552.
- Морозова А.Ю., Зубков Е.А., Кошкин Ф.А., и др. Экспрессия генов, кодирующих серотониновые рецепторы и SERT в различных структурах мозга у стрессированных хроническим воздействием ультразвука крыс // Бюллетень экспериментальной биологии и медицины. 2013. Т. 156. № 9. С. 291–294.
- Chen F., Danladi J., Wegener G., et al. Sustained Ultrastructural Changes in Rat Hippocampal Formation After Repeated Electroconvulsive Seizures // The international journal of neuropsychopharmacology. 2020. Vol. 23, N7. P. 446–458.
- Giacobbe J., Pariante C.M., Borsini A. The innate immune system and neurogenesis as modulating mechanisms of electroconvulsive therapy in pre-clinical studies // Journal of psychopharmacology (Oxford, England). 2020. Vol. 34, N10. P. 1086–1097.
- Kowiański P., Lietzau G., Czuba E., et al. BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity // Cellular and molecular neurobiology. 2018. Vol. 38, N3. P. 579–593.
- Duman R.S., Deyama S., Fogaça M.V. Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants // The European journal of neuroscience. 2021. Vol. 53, N1. P. 26–139.
- Björkholm C., Monteggia L.M. BDNF – a key transducer of antidepressant effects // Neuropharmacology. 2016. Vol. 102. P. 72–79.
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