The study of TRPV1 channelsof the central nervous systemand their effect on anxiety in ICR mice

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The TRPV1 channel is actively involved in various neuronal processes and is found in various structures of the nervous system, including peripheral and central neurons, sensory ganglia, spinal cord and various parts of the brain. Due to its ability to respond to various stimuli, TRPV1 can have a significant impact on the body’s responses to stress. Studies indicate the involvement of TRPV1 in the regulation of anxiety behavior. Suppression of TRPV1 activity leads to a decrease in the level of anxiety in animals, which indicates the importance of this channel in psychoemotional regulation. A promising compound for inhibiting this channel is the APHC3 peptide, which is a selective receptor antagonist. The results obtained in the course of our study show that this peptide has a pronounced anxiolytic effect, reducing the level of anxiety in the studied animals.

作者简介

V. Pavlov

Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Pushchino Branch of Russian Biotechnological University

编辑信件的主要联系方式.
Email: v.m.pavlov29@gmail.com
俄罗斯联邦, Pushchino; Pushchino

A. Fedotova

Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Pushchino Branch of Russian Biotechnological University

Email: v.m.pavlov29@gmail.com
俄罗斯联邦, Pushchino; Pushchino

Y. Andreev

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: v.m.pavlov29@gmail.com
俄罗斯联邦, Moscow

V. Palikov

Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Pushchino Branch of Russian Biotechnological University

Email: v.m.pavlov29@gmail.com
Pushchino; Pushchino

I. Dyachenko

Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Pushchino Branch of Russian Biotechnological University

Email: v.m.pavlov29@gmail.com
俄罗斯联邦, Pushchino; Pushchino

参考

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