The influence of antiepileptic drugs on menstrual and reproductive function of women (review of literature)

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Abstract

The article presented more fully set forth the theory of occurrence of disorders of the reproductive function of women taking anti-epileptic therapy and put forward his own theory of the mechanism disorders in patients receiving valproic acid preparations.

Full Text

The article presented more fully set forth the theory of occurrence of disorders of the reproductive function of women taking anti-epileptic therapy and put forward his own theory of the mechanism disorders in patients receiving valproic acid preparations.
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About the authors

E V Tsallagova

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: secretariat@oparina4.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

V O Generalov

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: videoeeg@mail.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

T R Sadykov

Center of diagnostics and treatment for epilepsy “Planeta Med”

Email: videoeeg@mail.ru
117105, Russian Federation, Moscow, Varshavskoe sh., d. 13

V V Borovkova

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: secretariat@oparina4.ru
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

References

  1. Бабичев В.Н. Нейроэндокринная регуляция репродуктивной системы. Пущино, 1995.
  2. Бабичев В.Н. Нейроэндокринология пола. М.: Наука, 1981.
  3. Вилков Г.А., Нестеренко Э.Н., Колмакова Т.С. и др. Гормональные взаимоотношения при симптоматической эпилепсии. Журн. неврологии и психиатрии. 1994; 94 (4): 6-9
  4. Власов П.Н. Алгоритмы диагностики и терапии эпилепсии у взрослых в поликлинических условиях. Фарматека. 2005; 7: 96-104
  5. Власов П.Н. Медикаментозная терапия - основа реабилитации больных эпилепсией женщин. В кн.: Актуальные вопросы медицинской нейрореабилитации. М., 1996.
  6. Власов П.Н. Некоторые клинические, социальные, гормональные, ЭЭГ и терапевтические особенности эпилепсии у женщин. В кн.: Успехи современной неврологии. М.: МГМСУ, 1999.
  7. Гехт А.Б., Авакян Г.Н., Гусев Е.И. Современные стандарты диагностики и лечения эпилепсии в Европе. Журн. неврологии и психиатрии. 1999; 7: 4-7.
  8. Гусев Е.И., Белоусов Ю.Б., Гехт А.В. и др. Лечение эпилепсии: рациональное дозирование антиконвульсантов. СПб., 2000.
  9. Зенков Л.Р. Как улучшить лечение эпилепсии в России? Рос. мед. журн. 2003; 1: 3-9
  10. Илловайская И.А. Актуальные проблемы нейроэндокринологии. М., 2003.
  11. Карлов В.А. Судорожный эпилептический статус. М.: МЕДпресс-информ, 2003
  12. Карлов В.А., Власов П.Н. Беременность и лекарственная терапия эпилепсии. Новости эпилепсии. 1997; 2 (12): 6-7.
  13. Розен В.Б., Смирнов А.Н. Рецепторы и стероидные гормоны. М.: МГУ, 1981.
  14. Семичева Т.В. Заместительная терапия гипоталамо-гипофизарной недостаточности. М., 2001
  15. Уварова Е.В. Патогенетические аспекты и современные возможности коррекции гиперандрогенных проявлений у девочек-подростков. Лечащий врач. 2008; 3: 34-42
  16. Филатова Н.В. Особенности эпилепсии у женщин с нарушением менструальной функции. Автореф. дис.. канд. мед. наук. М., 2010.
  17. Цаллагова Е.В., Прилепская В.Н. Роль снижения избыточной массы тела в восстановлении функции репродуктивной системы женщины. Гинекология. 2005; 7 (1): 51-3.
  18. Юдаев Н.А. Биохимия гормонов и гормональной регуляции. М.: Наука, 1976.
  19. Arimatsu Y, Hatanaka H. Estrogen treatment enhances survival of cultured fetal rat amygdala neurons in a defined medium. Dev Brain Res 1986; 26: 151-9.
  20. Barrett-Connor E, Kritz-Silversten D. Estrogen replacement therapy and cognitive function in older women. JAMA 1993; 269: 2637-41.
  21. Bauer J, Burr W, Elger C.E. Seizure occurrence during ovulatory and anovulatory cycles in patients with temporal lobe epilepsy: a prospective study. Eur J Neurol 1988; 5 (1): 83-8.
  22. Bauer J, Jarre A, Klingmuller D et al. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 2000; 41: 163-7.
  23. Bonucelli U, Melis G.B, Paoletti M et al. Unbalanced progesterone and estradiol secretion in catamenial epilepsy. Epilepsy Res 1989; 3: 100-6.
  24. Corpéchot C, Robel P, Axelson M et al. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA 1981; 78 (8): 4704-7.
  25. Crivello J.F, Jefcoate J. Intracellular movement of cholesterol in rat adrenal cellc. Kinetics and effects of inhibitors. J Biol Chem 1980; 255 (17): 8144.
  26. Duncan S, Brodie M.J. Sexual function in women with epilepsy. Epilepsia 1997; 38: 1074-81.
  27. Flood J.F, Smith G.E, Roberts E. Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 1988; 447 (2): 269-78.
  28. Gee K.W, Chang W.C, Brinton R.E et al. GABA-dependent modulation of the C1-ionophre by steroids in rat brain. Eur J Pharmacol 1987; 136 (3): 419-23.
  29. Hamed S.A. Neuroendocrine hormonal conditions in epilepsy: relationship to reproductive and sexual functions. Neurologist 2008; 14: 157-69.
  30. Herzog A.G, Friedman M.N. Menstrual cycle interval and ovulation in women with localization-related epilepsy. Neurology 2001; 57: 2133-5.
  31. Herzog A.G. Three pattern of catamenial epilepsy. Epilepsia 1997; 38 (10): 1082-8.
  32. Herzog A.G, Seibel M.M, Schomer D.L et al. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 341-6.
  33. Isojarvi J.I.T. Serum steroids hormones and pituitary function in femail epileptic patients during carbazepine. Amer Neurol 1989; 46: 1175-8.
  34. Karceski S, Morrell M.J, Carpenter D. Treatment of epilepsy in adults: expert opinion. Epilepsy Behav 2005; 7 (1): 64.
  35. Karlov V.A, Vlasov P.N, Kuschlinsky N.E et al. Syndrome of lactorrea and epilepsy. Epilepsia 1998; 39 (2): 113.
  36. Kimura D. Sex differences in the brain. Sci Amer 1992; 267: 119-25.
  37. Li P.K, Rhodes M.E, Jagannathan S. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Brain Res Cogn Brain Res 1995; 2 (4): 251-4.
  38. Löfgren E, Mikkonen K, Tolonen U et al. Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication. Epilepsy Behav 2007; 10 (1): 77-83.
  39. Mahesh V.B, Brann D.W. Regulation of the preovulatory gonadotropin surge by endogenous steroids. Steroids 1998; 63: 616-29.
  40. McEwen B.S, Alves S.E. Estrogen actions in the central nervous system. Endocr Rew 1999; 20: 279-307.
  41. Ming X, Kaplan P.W. Fixation-off and eyes closed catamenial generalized nonconvulsive status epilepticus with eyelid myoclonic jerks. Epilepsia 1998; 39 (6): 664-8.
  42. Morrell M.J, Hayes F.J. High incidence of components of polycystic ovary syndrome in young women with epilepsy treated with valproate versus lamotrigine. Epilepsia 2005; 46 (8): 88.
  43. Morrell M.J, Sperling M.R, Stecker M. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology 1994; 44: 243-7.
  44. Murialdo G, Galimberti C.A, Magri F. Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. J Endocrinol Invest 1997; 20: 519-26.
  45. Ohno Y, Yanagibashi K. A possible role of “steroidogenic factor” in the corticoidogenic response to ACTH; effect of ACTH, cycloheximide and aminoglutethimide on the content of cholesterol in the outer and inner mitochondrial membrane of rat adrenal cortex. Endocrinol Jap 1983; 30 (3): 335.
  46. Privalle C.T, Crivello J.F, Jefcoate C.R. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P450 in rat adrenal gland. Mol Cell Endocrinol 1987; 53: 87.
  47. Pschirrer E.R. Seizure disorders in pregnancy. Obstet Gynecol Clin North Am 2004; 31 (2): 373-84.
  48. Quigg M, Kiely J.M, Shneker B et al. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 2002; 51: 559-66.
  49. Rainey W.E, Nakamura Y. Regulation of the adrenal androgen biosynthesis. J Steroid Biochem Mol Biol 2008; 108 (Iss. 3-5): 281-6.
  50. Tuveri A, Paoletti A.M, Orru M et al. Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. Epilepsia 2008; 49: 1221-9.

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