Vol 18, No 5 (2016)

Purpose of the study is to determine the frequency of the use of emergency contraception among young people and awareness of the emergency contraception in the youth environment. Material and methods. Analysis of data from anonymous questionnaires was received from 952 people from various educational institutions and by the young doctors of various specialties. The gender composition of participants was: girls - 802 (84.2%), boys -150 (15.8%) aged 15 to 24 years (mean age 20.7±1.6 years). Results. Pregnancy rates among young people is 9.9% and increases with age. Two-thirds of pregnancies were medically aborted. Every third woman (32.9%) has an experience in using emergency contraception. For the levonorgestrel, emergency contraception is used. Awareness about emergency contraception is low.

This article presents the results of randomized, blind, placebo-controlled prospective study in parallel groups. 40 premenopausal women with symptoms of climacteric syndrome, menstrual disordersand FSH level more than 20 mIu/ml, were recruited and randomized into 2 groups: 20 women (group 1) used placenta extract Melsmon (Japan), 2 ml (100 mg), subcutaneously, every 2nd day for 2 weeks, then 2 time a week (30 injections for 4 months in total). 20 patients (group 2) were included in the placebo group (2 ml subcutaneously, in similar regimen). After 4 months of treatment the significant decrease of modified Kupperman menopausal index, decrease of time required tofall asleep and night time awakenings number, as far as increasing of sleep duration and significant improvement of general health self-assessment were registered in both groups. The improvement of psycho-emotional symptomsand skin condition after intervention was reported only in the 1st group. 32% of women used placental extract and 5% patients from placebo group reported about menstrual episodes after period of amenorrhea, without any significant changes in endometrial thickness. Study limitations: because of the small sample size and limited observation period, more long-term trials are needed.

Intrauterine adhesions (IUA) or Asherman's syndrome - multifaceted condition, which is being diagnosed with increasing frequency in recent years and a major cause of secondary infertility. Despite the widespread adoption of hysteroscopic adhesiolysis, the management of IUAs still presents a big challenge: the recurrence rate could be up to 62.5% in severe IUAs. The literature review highlights the current capabilities of surgical treatment, methods and means of prevention of recurrence, as well as the most promising research into the pathogenesis and treatment of Asherman's syndrome.

Objective: To evaluate the efficacy and safety methods for termination of pregnancy in the late period of congenital fetal malformation incompatible with life. Materials and methods. A randomized comparative study in 2 stages (retrospective and prospective). On stage, I conducted a retrospective analysis of the termination of pregnancy in 150 women who were divided into 2 groups: Group A - 75 women who underwent transvaginal method of transcervical amniocentesis. Under the prospective study (II stage) was 195 pregnant women were divided into 2 groups. The main group - 98 women with the combined method (medical combined with kelp); comparison group - 97 women (WHO scheme). Results. The efficiency of abortion (I stage) by amniocentesis was 93.3%, with prostaglandins - 92%. The effectiveness of the methods used abortion at stage II was 99.0% in the intervention group and 96.9% - in the comparison group. With a decrease in the length of time from the beginning of the method to the induction of late induced abortion in both groups there was a decrease in complications. The greatest number of complications observed in women with a duration of late induced abortion 24 hours or more. Conclusion. The advantages of the combined method has a shorter duration of time from the start of the method prior to uterine activity, due to the mechanical action of kelp on the cervix. A smaller dose of mifepristone (3 times) and a lower dose of misoprostol (2-fold) in the combined process has reduced adverse events (4.2 times).

In the given review of the article, the data on the frequency, pathogenesis of breast disease, including cancer is presented. The general aspects of risk factors such as benign breast disease, and for breast cancer are also given. The modern types of classifications and survey methods in patients with breast disease, as well as the role of multi-disciplinary approach, namely continuity between the doctors of various specialties: obstetricians, mammalogy, surgeons, oncologists, and morphology are listed as well. The advantages of efficacy and safety of non-hormonal drug Mamoclam in the pathology of the mammary glands are many. As a result of the action of iodine, polyunsaturated fatty acids and omega-3 chlorophyll included in the preparation of laminaria (Mamoclam), normalization occurs and the balance of thyroid hormones, cells, cell proliferation in breast tissue, which has a therapeutic effect in patients with fibrocystic disease. The clinical efficacy of Mamoclam from the kelp reaches 90%. The modern approach of rational strategies for any disease, including breast pathology, carried out on two principles: the existence of evidence and regulatory documents is described in detail.