Vol 18, No 4 (2016)

This article provides information on acromegaly, highlighting the diagnostic algorithm of search and therapeutic tactics in detecting the disease in women of reproductive age. Based on the above clinical case described medical tactics in the management of pregnant women with acromegaly.

The article describes the history of development of the concept of primary prevention of congenital malformations of the fetus via periconceptional receiving of multivitamin preparations containing folic acid. The results of Hungarian studies on the use of multivitamins are also given below as well as the current understanding of the mechanism of the prophylactic action of folic acid from a position of pharmacogenetics. The data on the use of different biochemical forms of folate is presented as well.

Human papillomavirus is likely the most common sexually transmitted viral infection worldwide. HPV provokes anogenital diseases and genital warts. It should be noted the specific importance of the quality of life assessment of the women with human papillomavirus - associated cervical diseases.

Goal. The study of changes in mental and emotional state in patients with polycystic ovarian syndrome before you start taking a hormonal contraceptive containing estradiol valerate (E2V) in combination with dienogest (DNG) in dynamic mode and after 12 months against a background of continued administration. Materials and methods. The study included 36 patients in need of contraception (aged 22 to 31 years), with the presence of symptoms of hyperandrogenism and menstrual irregularities. All patients completed self-assessment questionnaires for mental and emotional state before the reception and at 12 months in patients receiving hormonal contraceptive. Results. Hormonal contraceptive (E2V in combination with DTG) used in a continuous dynamic mode, has a positive therapeutic effect against clinical manifestations of hyperandrogenism and reproductive status of patients with PCOS. The therapeutic effect in combination with E2V dienogest was to authentic decrease in severity of symptoms of hyperandrogenism (acne, fat skin). In addition, in patients receiving hormonal contraceptive it noted improvements in mental and emotional state of patients with polycystic ovary syndrome, which is caused by a decrease in symptoms of hyperandrogenism, and the normalization of body weight (by diet).

The goal of anti-aging menopausal hormone therapy (MHT) lies in maintenance and restoration of the major organs and body systems, thus achieving two main effects: increasing life expectancy and improving its quality, which is fully consistent with the desires of women in perimenopausal and postmenopausal women. MHT started in the menopausal transition period is not only the treatment of early symptoms of menopause, but menopause itself and prevention of late complications. The article discusses the possibility and efficacy of Angeliq® Micro containing reduced doses of estrogen and progestogen (17β-estradiol 0.5 mg + drospirenone 0.25 mg). Indications for its purpose is to maintain moderate to severe hot flashes in postmenopausal women with an intact uterus.

Here are materials on the prevalence of modern contraceptive methods in the federal districts of Russian Federation.

Objective. To study the morphometric characteristics of eutopic and ectopic endometrial basal cells in patients with endometriosis and without. Material and Methods: The study involved 76 women aged 17 to 42 (average age was 28.97 ± 5.34 years). The main group consisted of 61 women with ovarian endometriosis, control group - 15 patients with infertility, not related to endometriosis. Results. Morphometric evaluation basal endometrial cells revealed that in patients with endometriosis compared with patients without a thickness of 1.25 times lower than the cytoplasmic membrane thickness gland - 1.5 times the thickness of the nuclear membrane - 1.2 times higher average brightness - 1.2 times lower average density - 1.2 times higher. When comparing eutopic and ectopic endometrial cells in endometriosis patients with the following data: the core area is 1.7 times higher in the eutopic endometrial cells, secretory thickness of the cage 2-fold higher in the eutopic endometrial cells, cytoplasmic membrane thickness is 1.3 times higher eutopic endometrial cells, the average density is 1.2 times higher in the cells of ectopic endometrial average brightness 1.19 times higher in eutopic endometrial cells. Conclusion. The results of our work have demonstrated the obvious statistically significant differences in the morphometric analysis of the basal epithelial cells of eutopic between female patients with endometriosis without it. Consequently, not only stem cells from different ectopic foci localization eutopic cells, but the cells themselves and the basement membrane, which are located on mesenchymal stem cells on their morphometric characteristics are distinct and different from endometrial cells without endometriosis patients.