Vol 19, No 4 (2017)


Prostaglandins and anti-prostaglandins in pathogenesis and treatment of primary dysmenorrhea

Mezhevitinova E.A., Prilepskaya V.N.


The article deals with modern theories of the pathogenesis of dysmenorrhea. A special place is given to prostaglandin, an anti-prostaglandin theory. As a therapy for dysmenorrhea, the group of prostaglandin-synthetase inhibitors is considered in detail. The article presents the results of our own study of the clinical efficacy of ketoprofen lysine salt in 50 patients diagnosed with primary dysmenorrhea.
Gynecology. 2017;19(4):4-9
pages 4-9 views

Characteristics of the vaginal microbiota with a combination of bacterial vaginosis with the pathology of the vagina and cervix inflammatory genesis

Pestrikova T.Y., Yurasova E.A., Kotelnikova A.V.


The article is devoted to investigation microbiocenosis of the genital tract reproductive age women with the combination of bacterial vaginosis together with pathology of vagina and cervix of the inflammatory genesis. The study of microbiota with bacterial vaginosis showed that the microflora is not identical, but at the same time, depends on the combination of bacterial vaginosis with other nosological forms (cervicitis, vulvovaginal candidiasis). The frequency of relapse with the combination of bacterial vaginosis with cervicitis and vulvovaginitis candidiasis was significantly higher than with a pure form of bacterial vaginosis. All this is important in choosing treatment methods. The combination of several nosological forms (bacterial vaginosis, cervicitis, vulvovaginal candidiasis) leads to a significant increase in adverse outcomes of pregnancy and childbirth.
Gynecology. 2017;19(4):15-19
pages 15-19 views

Genetic predisposition to a recurrent course of vulvovaginal candidiasis

Pogosyan S.M., Mezhevitinova E.A., Donnikov A.E., Prilepskaia V.N., Burmenskaia O.V., Nepsha O.S., Bystritskiy A.A.


Vulvovaginal candidiasis (VVC) frequently occur in women of childbearing age. 5-10% of these women experience recurrent vulvovaginal candidiasis (RVVC), which is characterized by at least 4 episodes of infection in 12 months. In addition to known risk factors such as antibiotics, diabetes, or pregnancy, host genetic variation and antifungal immune response play a substantial role in the pathogenesis of RVVC. The aim of this study was to identify a molecular-genetic factors of recurrence of VVC. Our results shows that single nucleotide polymorphisms (SNP) in cytokine genes such as IL4, IL1b and CCL2 were associated with recurrent vulvovaginal candidiasis and effect on susceptibility to disease.
Gynecology. 2017;19(4):20-25
pages 20-25 views

Correctness of use of microdosed combination oral contraceptives in young women

Buralkina N.A.


The article describes the effective use of a microdosed combined oral contraceptive containing drospirenone in young women. The use of synthetic progestin IV generation due to antiandrogenic and unique antimineralocorticoid effects makes it possible to obtain an additional spectrum of medicinal properties, has a high contraceptive effectiveness, is well tolerated, reduces the symptoms of premenstrual syndrome, acne, and seborrhea with virtually no effect on body weight in young women.
Gynecology. 2017;19(4):26-29
pages 26-29 views

Management of endometriomas

Dubrovina S.O., Berlim Y.D., Gimbut V.S., Krasilnikova L.V., Areshyan K.A.


Ovarian endometriomas could affect up to 44% of women with endometriosis, and are often associated with pelvic pain and infertility. Treatment options include expectant management, medical and/or surgical treatment, and in vitro fertilization. The choice of treatment depends mostly on the associated symptoms. In most cases, surgery is the preferred choice, since endometriomas do not respond to medical treatment, which may only treat associated pain. In case of infertility, in vitro fertilization and embryo transfer may be a suitable alternative to surgery, particularly when there is no associated pain. According to the best available scientific evidence, laparoscopic excision of the endometrioma wall should be considered the procedure of choice. The surgical excision may damage the ovarian reserve. At the same time, recent evidences demonstrate that part of the damage may be due to the presence of the endometrioma itself. Indication to surgical treatment should balance the possible risks of damaging the ovarian reserve with the advantages of surgery in terms of satisfactory pain relief rates and pregnancy rates, and of obtaining tissue specimen for ruling out the rare cases of unexpected ovarian malignancy. A score system to guide the clinician in the decision to perform or withhold surgery and endometriosis fertility index are presented.
Gynecology. 2017;19(4):30-35
pages 30-35 views

Personal selection of hormonal contraception

Kuznetsova I.V.


Hormonal contraception is a highly effective means of protecting against unwanted pregnancy and has been widely used throughout the world for more than 50 years. Unfortunately, in Russia, women still do not often use hormonal contraceptives as residents of Europe, North and South America. One of the reasons for the lack of proper distribution of hormonal contraceptives in our country remains insufficient awareness of the useful properties of contraception, along with an exaggerated view of the negative consequences of taking hormones, as well as a lack of time for the medical worker to provide adequate counseling. To overcome this problem, it is necessary to create easy-to-use algorithms of the practitioner's actions that help to simplify and optimize the choice of hormonal contraceptive for each specific woman depending on her health status, reproductive status and age. This publication contains an example of such an algorithm, including options for prescribing oral contraceptive drugs for different groups of women.
Gynecology. 2017;19(4):36-43
pages 36-43 views

Hemangioma of the ovaries: a review of the literature and a description of the clinical case

Korennaya V.V., Golubev S.S., Puchkov K.V., Agisheva V.V.


Hemangiomas of the ovaries are rare benign tumors that develop as a result of congenital malformation of blood vessels. Most often they are small in size and are a random finding during the operation or at autopsy. In rare cases, they can reach large sizes and cause discomfort in the lower abdomen, an increase in the level of cancer markers, and a number of other symptoms. In the literature, no more than 60 patients are described, with a confirmed diagnosis of ovarian hemangioma. We give a description of the case of detection of bilateral asymptomatic hemangiomas of the ovaries in a patient 59 years after performing pantheisterectomy.
Gynecology. 2017;19(4):44-46
pages 44-46 views

Clinical case: cryopreservation of ovarian tissue from girl 15 years

Buralkina N.A., Chuprynin V.D., Borisenko M.Y., Uvarova E.V., Kuzemin A.A., Abubakirov A.N., Ezhova L.S., Asaturova A.V.


The article presents a clinical case of cryopreservation of ovarian tissue in a patient 15 years with the bulk formation of a single ovary, is made on the basis of V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.
Gynecology. 2017;19(4):47-49
pages 47-49 views

Placental insufficiency and threatened miscarriage: a modern view on the problem

Voevodin S.M., Shemanaeva T.V., Shegolev A.I.


Analysis of clinical and morphological data of 101 cases complicated by placental insufficiency have performed. In all cases, pathomorphological verification of the placenta had carried out. Obstetric complications were accompanied by activation of immuno-inflammatory process in placental tissue.
Gynecology. 2017;19(4):50-52
pages 50-52 views

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