Vol 17, No 5 (2015)

Articles
Chromium, selenium, molybdenum: nutritional importance in support of pregnancy
Gromova O.A., Torshin I.Y., Serov V.N., Grishina T.R., Tetruashvily N.K.
Abstract
Pregnancy is the special female condition. During this period, you are obliged to take care of yourself, your health, your food and drink and medications you use. It is during this period when major changes occur as well as the needs of women themselves - in fact they should supply the body with nutrients, vitamins and minerals not only themselves, but also the unborn child. Recently, of particular importance in the physiological support of pregnancy are micronutrients such as chromium, selenium and molybdenum. Chromium normalizes metabolism of sugars, prevents formation of insulin resistance, has immunomodulatory and anti-hyperlipidemic action. Molybdenum is needed for the prevention of anemia in pregnant women and the formation of congenital malformations in the fetus. Selenium is essential for nutritional periconceptual support, prevention of disorders of lipid metabolism and cholestasis, and is essential for the functioning of the thyroid gland.
Gynecology. 2015;17(5):4-9
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Ultrasound and clinical-morphological evaluation of fetal-placental complex of pregnant women with intrauterine infection
Voevodin S.M., Shemanaeva T.V., Shchegolev A.I.
Abstract
Analysis of ultrasound and clinical and morphological data of 52 cases complicated by placental insufficiency and the presence of intrauterine infection have performed. In all cases, pathomorphological verification of the placenta had carried out. Ultrasound markers-predictors of early complications of placental insufficiency and intrauterine infection had identified.
Gynecology. 2015;17(5):10-13
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Differential diagnosis of subclinical isolated increase of hepatic transaminases in the second half of pregnancy
Uspenskaya Y.B., Kuznetsova I.V.
Abstract
The review examines the problem of increase of liver transaminases in the second half of pregnancy. ALT and AST reflect processes of hepatocyte injury, but are not specific for the diagnosis of a particular disease of the liver. However, determining the cause of changes of liver samples in a short time in pregnant women is extremely important because of the significant differences in prognosis for the mother and the fetus, and the tactics of treatment and management of patients. Authorspresent algorithm of differential diagnosis of obstetric and non-obstetric causes of enlarged alanine aminotransferase and aspartate aminotransferase in the later stages of gestation.
Gynecology. 2015;17(5):14-18
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The role of adequate iodine intake during pregnancy in the prevention of violations of intelligence in children: choosing the iodine-containing drugs dosage
Kurmacheva N.A.
Abstract
The importance of accurate in prevention of iodine deficiency for planning pregnancy and pregnant women, with emphasis on its main purpose - to ensure the harmonious development of the brain of the fetus and child and prevention of cognitive impairment in offspring is discussed in this article. The importance of compliance with the modern principles of iodine prophylaxis - to ensure adequate iodine intake before conception and throughout pregnancy and breastfeeding, is demonstrated.
Gynecology. 2015;17(5):20-23
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A meta-analysis of clinical studies on the use of iron fumarate for the prevention and treatment of iron deficiency anemia in pregnant women
Torshin I.Y., Gromova O.A., Limanova O.A., Grishina T.R., Bashmakova N.V., Kerimkulova N.V., Serova O.F., Kraposhina T.P., Kosenko I.M.
Abstract
Iron fumarate, especially in combination with vitamins is an important form of iron for use in the therapy and prophylaxis of iron deficiency anemia (IDA) in women of reproductive age. The results of a meta-analysis of 11 clinical trials of drugs iron fumarate, have incorporated in a total of 473 patients in the "Case" (receiving iron fumarate) and 470 in the group "Control". The average age of study participants was 30±5 years; patients took drugs based on iron fumarate at a dose of 20 to 150 mg/day, based on elemental iron: an average of 58±21 mg/day, where 58 mg/day - average value (M), and 21 mg/day - the standard deviation (m). Preparations were made for 41±25 days. In 10 of the 11 studies used the drug on the basis of iron fumarate - Ferretab. Meta-analysis of the association between the drug intake and the risk of Ferretab various pathological states allowed to establish a significant decrease in the risk of iron deficiency anemia by 71% (RR 0.29, 95% CI 0.21-0.42, p=6.9¥10-11), the risk microcytosis - by 68% (RR 0.32, 95% CI 0.20-0.50, p=1.2¥10-5), the risk of reduced (less than 110 g/L) hemoglobin levels - by 62% (RR 0.38, 95% CI 0.20-0.50; p=1.1¥10-3) reduced the risk (less than 20 g/L) ferritin levels - by 63% (RR 0.37, 95% CI 0.24-0.56; p=7.1¥10-5) and reduced the risk (less than 20 mmol/liter) levels of serum iron - by 71% (RR 0.29, 95% CI 0.19-0.45; p=5.3¥10-7). Levels of serum iron and ferritin - the generally accepted criteria for evaluating the effectiveness of treatment of IDA. The side effects associated with Ferretab intake were not ascertained, including those of the gastrointestinal tract. Thus, this meta-analysis suggests that the drug Ferretab is effective and safe for the treatment of iron deficiency states.
Gynecology. 2015;17(5):24-31
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New features in the diagnosis of "lesser" abnormalities of cervical epithelium associated with HPV infection (review of literature)
Nazarova N.M., Prilepskaya V.N., Sycheva E.G., Zardiashvili M.D., Bourmenskaya O.V.
Abstract
In this review we observed the role of high risk HPV types in the development of epithelial lesions of the cervix. Modern data on the role of molecular genetic methods in the diagnosis of HPV-associated diseases are represented here. We analyze the literature on modern molecular biomarkers that shows the risk of proliferative processes in the transformation to neoplasia.
Gynecology. 2015;17(5):32-36
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Tolerability and patient satisfaction using different intrauterine contraceptive: results of the observation program MIRABEL
Andreeva E.N.
Abstract
The high incidence of unintended pregnancy remains a significant problem in many countries, including Russia. This figure can be significantly reduced when using reversible contraceptive methods for a long-acting, which include intrauterine levonorgestrel - therapeutic hormonal system and copper-containing intrauterine contraceptive means. Intrauterine remedies are highly assessed and effective, being characterized by a small number of contraindications and side effects with long-term economic viability application and can be a good choise for most women. The article presents the results of a multicenter non-interventional prospective comparative observational program, the main aim of which was to examine the tolerability of intrauterine and patient satisfaction results of their application.
Gynecology. 2015;17(5):37-43
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Melatonin in treatment of climacteric symptoms
Kuznetsova I.V., Burchakov D.I.
Abstract
During menopausal transition women develop vasomotor and psychosomatic symptoms. These symptoms stem both from estrogen deprivation and hypothalamic-pituitary system ageing. Melatonin is a powerful hormonal adaptogen, working at every level of reproductive system, down to receptor level. To measure its effect on climacteric symptoms, we enrolled 55 women between 45 and 65 y.o. All participants took 3 mg of melatonin - Melaxen (Unipharm, Inc.) for 3 months. During the therapy we observed marked reduction of symptoms from 40.96 to 21.36 (47.92%) on Greene Climacteric Scale and sleep improvement from 16.60±4.03 to 7.33±1.95 on Pittsburgh Sleep Quality Index. Melatonin 3 mg is an effective method of climacteric symptoms therapy.
Gynecology. 2015;17(5):44-48
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Additional aspects of the prediction of postmenopausal osteoporosis
Zakharov I.S., Kolpinskiy G.I., Ushakova G.A.
Abstract
The aim of the present work is to optimize the system prediction of osteoporosis in postmenopausal women. In the present study included 224 postmenopausal women aged up to 65 years, which examined the role of a low intake of calcium and vitamin D deficiency in the prediction of postmenopausal osteoporosis. When assessing the prognostic role of these factors method was used binary logistic regression. The area under the ROC-curve (AUC) was for the level of calcium intake - 0.781 (0.648; 0.913) for the concentration of vitamin D in serum - 0.730 (0.618; 0.843). Comprehensive assessment of studied predictors will increase the predictive value of existing models that determine the probability of occurrence of postmenopausal osteoporosis and optimize the prevention of bone loss in women.
Gynecology. 2015;17(5):49-51
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Pregravid training in patients with the operated ovaries in assisted reproductive technologies program
Serebrennikova K.G., Vanke E.S., Kuznetcova E.P., Ivanova T.V., Miloslavskiy Y.V.
Abstract
Pregravid training (PT) is an urgent problem in reproductology and is a complex of measures aimed at the favorable outcome of pregnancy and childbirth. Carrying out the PT allows to increase the percentage of pregnancy and reduce the risk of complications. PT is of great importance in patients who underwent surgery on the ovaries, because it is the primary mechanism that can improve the performance of pregnancy and childbirth in ART programs.
Gynecology. 2015;17(5):52-56
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Pathological conditions caused by magnesium deficiency in women at different ages
Zakharov I.S., Ushakova G.A., Kolpinskiy G.I.
Abstract
This paper presents a review of publications devoted to the conditions associated with magnesium deficiency in women. Considers the pathological processes occurring in different age and biological periods. Known role of the cation in the prevention of a number of obstetric complications such as premature labor, eclampsia, ischemic disorders of the central nervous system of the fetus. Well-grounded is the appointment of drugs of magnesium combined with vitamin B6 in the premenstrual tension syndrome, post-menopausal disorders. The complex of magnesium and pyridoxine has a protective effect by using combined hormonal contraception and menopausal hormone therapy, reducing the side effects of these drugs. The combination of magnesium drugs increases the efficiency of correction of osteoporosis. Thus, the use of magnesium-containing drugs in combination therapy to reduce the risk of some serious obstetric complications and help to cope with a number of states, reducing the quality of life of women.
Gynecology. 2015;17(5):57-60
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