Vol 17, No 4 (2015)

For the treatment of genitourinary disorders is an effective means of appointment of local forms of estriol. The article presents the results of assessing the impact of estriol on the breast using the method of electrical impedance mammography. The absence of negative impact and no change in the state of mammary glands using local forms of estriol.

In the literary review the modern data proving an important physiological role of vitamin D and its deficiency for women’s health in postmenopausal period is presented. Vitamin D deficiency is associated with health risks including the cardiovascular diseases, cancer, strength of bones, obesity, insulin resistance, multiple sclerosis, diabetes, mental health problems. High percentage of women of postmenopausal age is deficient in vitamin D, medicamentous correction of vitamin D deficiency can have a huge impact on the health care strategy in the prevention of various diseases in postmenopausal period.

Proliferative diseases of the uterus, including uterine fibroids, endometriosis, endometrial hyperplasia are characterized by a rather wide distribution in the structure of gynecological pathology offset towards the younger population. These diseases are often combined in the same patient, which complicates the treatment of this group of patients and increases the frequency of relapses.

In this article there are shown cohort prospective research results of 25-hydroхуholecalciferol level estimation in blood serum during pregnancy among women depending on the season of the year. The aim of this research is to estimate the intensity of the body of pregnant women with vitamin D in different seasons during pregnancy, who live in Saint Petersburg. There are involved 205 pregnant at I trimester. It was finished by 192 patients. All patients were divided into 4 subgroups depending on the season of the year while involving to the study. At 12-14 weeks there was first blood sampling. From the I trimester till delivery all patients took 500 IU of сolecalciferol contained in multivitamin complexes. During pregnancy 25-ОН-D level in blood serum was measured at 12-14, 24-26, 34-36 weeks of gestation. There are not found significant differences of the initial mean level of 25-ОН-D in all pregnant (17.5, 21.3, 22.6, 19.9 ng/ml, accordingly to the 1st, 2nd, 3rd and 4th subgroups). It was defined the maximal intensity of vitamin D at I trimester of pregnancy during summer - 22.6 ng/ml, which refers to the criteria of vitamin D insufficiency. Minimal concentration of 25-ОН-D among subgroups was revealed during winter - 17.5 ng/ml, which refers the criteria of vitamin D deficiency. Total concentration of 25-ОН-D authentically does not differ between subgroups. The increase the level of 25-ОН-D from the I to the III trimester takes place regardless of the season. The study showed no significant changes in the level of 25-OH-D in blood serum of pregnant depending on the season.

The review presents the current data on the approach to the management of vulvovaginal candidosis (VVC). It is shown that the main current trend in the management of acute VVC is the use of short courses of antifungal therapy with a local application of azole. Fenticonazole is currently the drug of choice in the treatment of VVC has a high efficiency and safety.

In the article from the contemporary positions the effectiveness of the local treatment of vaginal discharge is examined. Is evaluated the role of the combined preparations at treatment and preventive maintenance of vaginal infections.

This article provides information about traditional and alternative approaches to the etiotropic treatment of chronic endometritis, the side effects of antibiotics, based clinical practicability of using bacteriophages and it's advantages in case of inflammation of endometrium.