Vol 15, No 3 (2013)

Articles
Human papillomavirus infection – new perspectives on diagnosis and treatment (review)
Bestaeva N.V., Nazarova N.M., Prilepskaya V.N., Trofimov D.Y., Burmenskaya O.V., Sulamanidze L.A.
Abstract
In the present review analyzed data from epidemiological studies of the prevalence of different types of human papillomavirus (HPV) on the Asian and European regions and their relationship with the development of cervical intraepithelial neoplasia and cervical cancer. The data of the literature on the little-known high-risk HPV types of HPV 52 and 58. Questions of risk of a persistention HPV, depending on the type of HPV, duration of a persistention, age of the woman, as the most important factor in the progression of pre-cancer and cervical cancer are considered.
Gynecology. 2013;15(3):4-7
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The efficacy and safety of genistein in the treatment of vasomotor symptoms in postmenopausal women (research review)
Kuznetsova I.V.
Abstract
The review discusses the efficacy and safety of phytoestrogens, preferably soy isoflavones in treating the menopausal syndrome symptoms. Particular attention is paid to the synthetic genistein. The highest genistein efficacy, when compared to other phytoestrogens is confirmed by comparative and placebo-controlled trials. However, prolonged use of genistein does not affect the proliferate processes in the endometrium and breast. Genistein can be considered a good alternative to hormone therapy when it is proved to be impossible or undesirable.
Gynecology. 2013;15(3):7-12
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Contraceptive and therapeutic effects of drospirenone-containing hormonal antifertility agent with 24/4 dosage regimen
Gevorkian M.A., Manukhin I.B., Kuznetsov M.I., Smirnova S.O.
Abstract
This paper focuses on the use of combine hormonic contraceptive Dimia in young patients' acne treatment. It owes its effecteveness to progestin drospirenone which has high anti-androgenic activity. Prolonged treatment – by 24/4 regimen stabilizes the hormone concentration in blood due to the pituitary gonadotrophic function suppression. This dosage scheme also heightens the premenstrual syndrome and androgen dependent dermatotoses treatment efficiency.
Gynecology. 2013;15(3):14-16
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On the management of menopause syndrome patients
Tatarova N.A., Gavrilova N.P.
Abstract
Research objective. Development of a program of follow-up for women with menopausal metabolic syndrome and cholestasis; determination of the effectiveness of the Femoston in combination with Ursofalk. Materials and methods. 71 women with climacteric syndrome, obesity and cholestasis were under observation; a comprehensive clinical and laboratory examination was carried out, measurement of modified menopausal index before treatment and after 6 months. The results. Positive changes in neurocirculation symptoms and lipid profile were obtained, a statistically significant reduction in transaminases and modified menopausal index, the coagulation parameters remained virtually unchanged. Conclusion. The Femoston and Ursofalk positively influence the climacteric syndrome; normalize lipid profile, having positive influence on the hepatobiliary system. It is appropriate to prescribe this medicine to the patients with menopausal metabolic syndrome and cholestasis.
Gynecology. 2013;15(3):17-19
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Modern treatment of premenstrual syndrome (review)
Kuznetsova I.V., Konovalov V.A.
Abstract
Premenstrual syndrome is a disease leading to the loss of quality of life and temporary disability. Currently, there are ways of not only relieving the symptoms and treatment of premenstrual syndrome, but also treating the patients with different therapy variations, that can provide a good quality of life of both patients and healthy women experiencing discomfort before the menses. The use of drospirenoncontained combined oral contraceptives solves this medical and social problem.
Gynecology. 2013;15(3):20-25
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Theresults of Computer Morphometryusedin Endometrial Hyperplasia
Tabakman Y.Y., Manukhin I.B., Solopova A.G., Kanibolotsky A.A., Bishtavi A.K., Gornykh O.A., Samoylenko V.V.
Abstract
Differencial diagnostics of simple, complex and atypical hyperplasia and endometrial cancer(SEH, CEH, AEH, EC) presents a number of difficulties which often lead to a different interpretation of the same histologic samples. Theaim: to evaluate the ability of computer morphometry used in case of endometrial hyperplasia. Material: 36 patients, including 12 patients with SEH, 11 patients with CEH, 7 patients with AEH and 5 patients with EC. Method of ImaScope Color morphometric programme.Conclusion: morphometric changes that occur in case of endometrial hyperplasia expressed in quantitative terms are more varied than their schematic definition in modern classification which in its turn may be the cause of the discrepanies in diagnoses.
Gynecology. 2013;15(3):26-28
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The use of human placenta hydrolyzate in the treatment of insufficient endometrial proliferation
Kuznetsova I.V., Sheveleva T.V., Pobedinskaya O.S., Uspenskaya Y.B., Gilels A.V.
Abstract
Endometrium dysfunction on the chronic endometritis background is a major cause of infertility and pregnancy loss. The effectiveness of chronic modern endometritis treatment methods is limited. In its basis, the chronic endometritis therapy is a directed action that can reduce the excessive endometrial inflammatory response while reinforcing its regenerative capabilities. The following paper presents the results of the randomized, open and comparative study of the human placenta hydrolyzate Laennek® when treating patients with chronic endometritis and/or failure of endometrial function. Also, the more effective placenta hydrolyzate use for the restoration of endometrial thickness, ovarian function in women with infertility and recurrent miscarriage compared with therapy hepatoprotectors vnitaminnymi and immunomodulatory drugs is demonstrated. Laennek® ‘s positive impact in pregravidal preparation of patients with chronic endometritis by the modulating effects on the immune and inflammatory processes, growth and function of endometrial ovarian autocrine and paracrine regulation.
Gynecology. 2013;15(3):29-33
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Some hematological characteristics of adenomyosis
Orazov M.R.
Abstract
In the given work are presented some hematological criteria of diagnostics of adenomyosis, is also explored opportunities to use the results of studies of the population composition of blood leukocytes and its relationship poly - and mononuclear cells in patients adenomyosis as predictors of this pathology.Studied in detail the data of an anamnesis and objective performance of the groups. The results of the study showed that, in general, the data obtained allow, in our opinion, the use of the study population composition of blood leukocytes and its relationship poly - and mononuclear cells (with granulocyte index) as a criteria for diagnosis, determine the effectiveness of the treatment, assessment and forecast predictor of tumor lesions ectopia in patients adenomyosis.
Gynecology. 2013;15(3):33-37
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The ovarian follicular reserve after electrosurgical treatment of ovarian endometriomas
Matveeva N.V., Ter-Ovakimyan A.E., Gasparov A.S.
Abstract
Analysisofthe results of surgical treatment in 76 patients of reproductive age after endosurgicalcuration of ovarian endometriomas has revealed that monopolar coagulation diminished an ovarian follicular reserve,modern markers of which (inhibin B and Müllerian inhibiting substance) were used.The assessment of frequency of approach of pregnancy within 12 months after expeditious treatment.
Gynecology. 2013;15(3):38-40
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Clinical and epidemiological peculiarities of cervical precancer in female residents of Omsk
Klinyshkova T.V., Turchaninov D.V., Samosudova I.B., Karatyuk T.I.
Abstract
Based the materials of an epidemiological sampling study of cervical precancer incidence it has been found: growth of primary CIN incidence (growth rate amounted to +7,9% according to the appealability data; p<0,001); dynamic change of CIN structure with CIN I domination: CIN I (45,7%) against CIN II (37,0%) and CIN III (17,8%), CIN I increment (Tincr.=+7,4%; p<0,001); a considerable change of CIN age structure tended to the disease predominance in 18–35 years patients (Tincr.=+11,3%; p<0,001). Through the 384 patients with CIN I–III complex examination against the background of HPV and 84 controls social risk factors of CIN development were found: early onset of sexual life, promiscuity, irregular barrier contraception or its absence (p<0,05), a slight interval between menarche and sexual debut (p=0,06). Thus, structure and value of CIN risk factors has not undergone vital changes against the background of CIN incidence growth.
Gynecology. 2013;15(3):40-44
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Immunologic and molecular-biological markers associated with chronic cervititis
Prilepskaya V.N., Nazarova N.M., Novikova E.P., Trofimov D.Y., Burmenskaya O.V., Beznoschenko O.S.
Abstract
The present literature review reports on the modern viewpoints on the problem of inflammations of the lower genital tract. The data of investigations of the role of local immunity and vaginal microflora in the development of chronic inflammations were assessed. The use of cytokine biomarkers in clinical practice was discussed and the results of proteomic studies of cervico-vaginal fluid in early diagnosis of inflammations were presented.
Gynecology. 2013;15(3):46-51
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Urogenital mycoplasma and its associations treatment option (clinical lecture)
Tikhomirov A.L.
Abstract
The azithromycin-containing Hemomycin and its compliance are discussed in this article. The use of this drug enhances compliance in the treatment of female genital organs inflammatory diseases.
Gynecology. 2013;15(3):52-57
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Female sexual dysfunction andurinary discomfort
Danilov V.V., Luchinskiy S.A., Danilova T.I., Danilov V.V.
Abstract
We observed a group of patients (35 women of mean age around 30). Within 7 weeks of a1-blocker (doxazosin 0,5–4 mg daily in combination with M-anticholinergic (trospium chloride 45 mg per day) therapy was conducted. Clinical picture of micturition disorders, quality of life and sexual activity of women was evaluated by means of tables. After the treatment, it was noted that urinary disorders ceased to have effect on the sexual life of patients. High efficiency correction of urinary disorders was confirmed in catamnesis up to 2 years after therapy discontinuation. Analysis of the symptoms dynamics and the results obtained showed that female sexual dysfunction as well as urinary disorders is one of the clinical manifestations of disorders of the lumbar spinal cord thickening.
Gynecology. 2013;15(3):58-61
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The clinical recommendations of diagnostics, treatment and prevention of iron-deficiency during pregnancy and puerperal period
Osipchuk D.O., Belomestnov S.R., Kulikov A.V.
Abstract
The clinical recommendations summarize world experience of diagnostics, treatment and prevention of iron-deficiency during pregnancy and puerperal period.
Gynecology. 2013;15(3):62-66
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Uterine fibroid – new possibilities of nosotropic therapy
Tikhomirov A.L.
Abstract
In this article are given the results of studies SMRP: ulipristal acetate in the treatment of uterine fibroids, ulipristal acetate (Esmya).
Gynecology. 2013;15(3):67-70
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Folate deficiency elimination: basic strategy homocysteine dependent correction of endothelial dysfunction
Tapilskaya N.I., Gaidukov S.N.
Abstract
Endothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeostasis depletion, namely, in a long flowing hyperhomocysteinemia by an imbalance in the antioxidant system of the body leads to a decrease in the number of endothelial progenitor cells, which reduces the regenerative capacity and plasticity of the vascular wall. Hyperhomocysteine when administered in excessive concentrations leads to inhibition of sodium-potassium adenosinetriphosphatase in the membrane of vascular smooth muscle cells, increasing intracellular sodium concentration, and thus leading to electrolyte disturbances that cause vasoconstriction becoming and essential element is a vicious circle of the underlying pathogenesis of both hypertension and preeclampsia. The use of contraceptives containing biologically active folate metafolin on preconception stage is a part of a targeted approach to the prevention of complications of pregnancy in women of reproductive age.
Gynecology. 2013;15(3):70-74
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