Vol 15, No 3 (2013)

The review discusses the efficacy and safety of phytoestrogens, preferably soy isoflavones in treating the menopausal syndrome symptoms. Particular attention is paid to the synthetic genistein. The highest genistein efficacy, when compared to other phytoestrogens is confirmed by comparative and placebo-controlled trials. However, prolonged use of genistein does not affect the proliferate processes in the endometrium and breast. Genistein can be considered a good alternative to hormone therapy when it is proved to be impossible or undesirable.

Research objective. Development of a program of follow-up for women with menopausal metabolic syndrome and cholestasis; determination of the effectiveness of the Femoston in combination with Ursofalk. Materials and methods. 71 women with climacteric syndrome, obesity and cholestasis were under observation; a comprehensive clinical and laboratory examination was carried out, measurement of modified menopausal index before treatment and after 6 months. The results. Positive changes in neurocirculation symptoms and lipid profile were obtained, a statistically significant reduction in transaminases and modified menopausal index, the coagulation parameters remained virtually unchanged. Conclusion. The Femoston and Ursofalk positively influence the climacteric syndrome; normalize lipid profile, having positive influence on the hepatobiliary system. It is appropriate to prescribe this medicine to the patients with menopausal metabolic syndrome and cholestasis.

Differencial diagnostics of simple, complex and atypical hyperplasia and endometrial cancer(SEH, CEH, AEH, EC) presents a number of difficulties which often lead to a different interpretation of the same histologic samples. Theaim: to evaluate the ability of computer morphometry used in case of endometrial hyperplasia. Material: 36 patients, including 12 patients with SEH, 11 patients with CEH, 7 patients with AEH and 5 patients with EC. Method of ImaScope Color morphometric programme.Conclusion: morphometric changes that occur in case of endometrial hyperplasia expressed in quantitative terms are more varied than their schematic definition in modern classification which in its turn may be the cause of the discrepanies in diagnoses.

In the given work are presented some hematological criteria of diagnostics of adenomyosis, is also explored opportunities to use the results of studies of the population composition of blood leukocytes and its relationship poly - and mononuclear cells in patients adenomyosis as predictors of this pathology.Studied in detail the data of an anamnesis and objective performance of the groups. The results of the study showed that, in general, the data obtained allow, in our opinion, the use of the study population composition of blood leukocytes and its relationship poly - and mononuclear cells (with granulocyte index) as a criteria for diagnosis, determine the effectiveness of the treatment, assessment and forecast predictor of tumor lesions ectopia in patients adenomyosis.

Based the materials of an epidemiological sampling study of cervical precancer incidence it has been found: growth of primary CIN incidence (growth rate amounted to +7,9% according to the appealability data; p<0,001); dynamic change of CIN structure with CIN I domination: CIN I (45,7%) against CIN II (37,0%) and CIN III (17,8%), CIN I increment (Tincr.=+7,4%; p<0,001); a considerable change of CIN age structure tended to the disease predominance in 18–35 years patients (Tincr.=+11,3%; p<0,001). Through the 384 patients with CIN I–III complex examination against the background of HPV and 84 controls social risk factors of CIN development were found: early onset of sexual life, promiscuity, irregular barrier contraception or its absence (p<0,05), a slight interval between menarche and sexual debut (p=0,06). Thus, structure and value of CIN risk factors has not undergone vital changes against the background of CIN incidence growth.

The azithromycin-containing Hemomycin and its compliance are discussed in this article. The use of this drug enhances compliance in the treatment of female genital organs inflammatory diseases.

The clinical recommendations summarize world experience of diagnostics, treatment and prevention of iron-deficiency during pregnancy and puerperal period.

Endothelial dysfunction is one of the most important pathogenetic mechanisms of both cardiovascular disease and uterine-placental microcirculation. Recent research shows that homocysteine plays a role of a forthcoming universal pathogenic factor in the case of mechanisms regulating cellular homeostasis depletion, namely, in a long flowing hyperhomocysteinemia by an imbalance in the antioxidant system of the body leads to a decrease in the number of endothelial progenitor cells, which reduces the regenerative capacity and plasticity of the vascular wall. Hyperhomocysteine when administered in excessive concentrations leads to inhibition of sodium-potassium adenosinetriphosphatase in the membrane of vascular smooth muscle cells, increasing intracellular sodium concentration, and thus leading to electrolyte disturbances that cause vasoconstriction becoming and essential element is a vicious circle of the underlying pathogenesis of both hypertension and preeclampsia. The use of contraceptives containing biologically active folate metafolin on preconception stage is a part of a targeted approach to the prevention of complications of pregnancy in women of reproductive age.